Abstract
We report a case of esophageal basaloid squamous cell carcinoma (BSCC) treated with salvage esophagectomy for the local recurrence after the definitive chemoradiotherapy (CRT). A 60-year-old man was seen for advanced pharyngeal cancer and found to have a synchronous early middle thoracic esophageal BSCC by screening endoscopy, and a consecutive CRT was attempted to control both cancers. Despite good control of the pharyngeal cancer, the patient developed local recurrence of esophageal BSCC one year after CRT and underwent a salvage esophagectomy. The histopathological stage was pStage I and no remarkable effect on the tumor from the CRT was observed (Grade 0). Microvascular invasion was not observed. The patient has survived 58 months since the salvage esophagectomy (84 months since the primary treatment) without any evidence of recurrence. BSCC of the esophagus has been reported with highly positive pathological microvascular invasion, even in early cancer, with poor prognosis. We considered that CRT using a combination chemotherapy of cisplatin and 5-FU was insufficient, therefore multi-modality treatment may provide a survival benefit for the patients with Stage I BSCC of the esophagus.
