Benign Lung Metastasizing Leiomyoma—A Report of 2 Cases—

Abstract

We report 2 cases of multiple benign lung-metastasizing leiomyoma in 2 women aged 51 and 58 years. In one case, the lesion was discovered on routine medical examination and in the other during examination for another disease. The lesions were multiple, large, bilateral nodules that were <12 mm in size without fluoro-D-glucose accumulation on positron emission tomography. Surgical biopsies were performed, and on histology, benign leiomyoma without mitosis was diagnosed. Immunohistological examination of the leiomyoma cells revealed the following features : negative for caldesmon, positive for alpha-smooth muscle actin, desmin, S-100, estrogen receptor, and progesterone receptor. Subsequently, one patient had a hysterectomy for a uterine myoma, whereas the other patient had a resection of a uterine myoma. In these 2 patients, benign lung metastasizing leiomyoma was caused by a uterine myoma ; they were followed without hormonal treatment being given.