Abstract
We report a case of gallbladder metastasis from renal cell carcinoma. A 43-year-old man underwent right nephrectomy for renal cell carcinoma with lung metastasis 1 year ago. After the operation, he was treated with IFN for lung metastasis. Approximately 1 year after he started IFN, follow-up CT detected a tumor in the gallbladder and he was referred to our department. Abdominal US demonstrated a 26-mm pedunculated polypoid lesion in the fundus of the gallbladder. Enhanced abdominal CT demonstrated an enhanced 20-mm solid mass in the gallbladder. MRI also revealed a solid mass in the gallbladder, which exhibited high-signal intensity on a T1-weighted image and low-signal intensity on a T2-weighted image. For metastatic gallbladder tumor from renal cell carcinoma or primary gallbladder cancer, the patient underwent extended cholecystectomy. The resected specimen contained a pedunculated polypoid tumor in the fundus of the gallbladder. The tumor was diagnosed as clear cell carcinoma. Immunohistochemically, the tumor cells were positive for EMA and vimentin, and negative for CK7 and CEA. We diagnosed the gallbladder tumor as metastasis from renal cell carcinoma. Gallbaladder metastasis from renal cell carcinoma is comparatively rare.
