Abstract
We describe a case of pancreatic hamartoma in a 67-year-old man. He initially presented with hyperglycemia and was referred to our center for valuation of a mass in the body of the pancreas. Dynamic CT demonstrated a well-circumscribed mass, measuring 20 mm, which showed weak enhancement in the portal venous phase. On MRI, the mass exhibited low-signal intensity on T1-weighted imaging and T2-weighted imaging, and weak enhancement similar to the CT images. Fine-needle aspiration biopsy of the tumor was performed by endoscopy under ultrasonic guidance. Pathologic evaluation showed no evidence of malignancy. Neuroendocrine tumor or tumor-forming pancreatitis was proposed as the preoperative diagnosis. The patient then underwent distal pancreatectomy. A well-demarcated solid nodule, 18 mm in diameter, was evident in the body of the pancreas. Microscopically, the lesion was composed of non-neoplastic, acinar cells and ducts embedded in a sclerotic stroma with elongated spindle cells, and without any islets of Langerhans. The stromal spindle cells stained immunopositive for CD34 and bcl-2. The histological diagnosis was a solid type of pancreatic hamartoma.
