Abstract
The case involved a man in his seventies, who underwent repeated transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) due to chronic hepatitis C, was admitted to our hospital for the treatment of a retroperitoneal tumor. The retroperitoneal tumor increased in diameter from 11 to 37 mm during the previous 1 year. Computed tomography (CT) revealed an enhanced retroperitoneal tumor behind the body of the pancreas, as well as a viable HCC in segment 4 of the liver. Levels of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and alpha-fetoprotein (AFP) were within the normal limits ; the level of protein induced by vitamin K absence/antagonist factor II (PIVKA-II) was 62 mAU/mL. On the basis of a diagnosis of metastatic retroperitoneal tumor of HCC, the patient underwent resection of the retroperitoneal tumor. Pathological examination of the resected specimen revealed a metastatic retroperitoneal tumor of HCC, and the serum level of PIVKA-II normalized after resection. Herein, we report a case of metastatic retroperitoneal tumor of HCC, along with a review of the literature.