Abstract
An 85-year-old Japanese woman presented to our hospital due to chronic right lower abdominal pain which had persisted for several decades. CT and MRCP showed a tumor lesion in the gallbladder. Intraoperatively, the gallbladder was found to be enlarged and to have invaded the surrounding transverse colon. We performed cholecystectomy, partial colectomy, and resection of the liver bed. An epithelial component, adenosquamous carcinoma with a mesenchymal component and spindle cell sarcoma with heterotopic bone formation were revealed by histopathological examination. In addition, epithelial membrane antigen, keratin, and/or vimentin were detectable in specimens by immunohistochemical staining. Therefore, we diagnosed carcinosarcoma with adenosquamous carcinoma. This is among the rarest gallbladder neoplasms. Our case has survived for seven years since the surgery, although the prognosis of patients with this disease is considered to be poor.
