Abstract
A 46-year-old premenopausal woman was found to have an abnormality on a breast ultrasound examination during her company checkup, and she came to our department for detailed examination. A lobulated mass lesion was observed in her inferior medial right breast, and she underwent follow-up observation. Two and a half years later, an architectural distortion was discovered on mammography. Since only an atypical lobule was observed on needle biopsy, a diagnosis could not be made, and an incisional biopsy was performed. The tissue diagnosis was tubular carcinoma ; nearby, columnar cells and non-invasive lobular carcinoma were observed. Pathologically, the findings included the triad of tubular carcinoma of the breast, columnar cells, and non-invasive lobular carcinoma coexisting together, which have been proposed as constituting the Rosen triad. The present case was diagnosed as tubular carcinoma of the breast with the Rosen triad. With the introduction of mammography for breast cancer screening, there has been an increase in the discovery of low-grade breast cancer cases, and pathological diagnosis has become more difficult, but the presence of this triad can be a basis for a definitive diagnosis of tubular carcinoma. Reaching a definitive diagnosis clinically enables determination of a treatment strategy and prediction of the prognosis, and therefore it is useful to have recognized the Rosen triad.
