Abstract
The patient was a 64-year-old male, who was diagnosed with hepatocellular cell carcinoma for the first time in 2004, and was treated with transcatheter arterial chemoembolization and radiotherapy. In June 2009, computed tomography revealed a 5 cm tumor mass on the body of the stomach. An endoscopic upper gastrointestinal study revealed an easily bleeding type I tumor on the body of the stomach. The pathological diagnosis of the biopsied specimen was poorly differentiated adenocarcinoma. The tumor was growing rapidly and anemia was present. Therefore, a total gastrectomy was performed in September 2009 to control the bleeding. A postoperative histopathological study revealed that the tumor, which was hyperplastic in the submucosal layer of the subserosa, had cord-like structures, hepatocellular-like traits, and no tubular adenocarcinoma. It was positive for hepatocyte specific antigen (HSA) immunostaining and negative for carcinoembryonic antigen (CEA) and cytokeratin 19 (CK19) immunostaining. These pathological findings and the clinical course supported the theory that the tumor was a metastasis of hepatocellular carcinoma to the stomach. The metastasis of hepatocellular carcinoma to the stomach is relatively rare. Only 38 cases, including ours, have been reported in Japan. We herein describe our experience with a case of metastasis of hepatocellular carcinoma to the stomach, along with a review of the literature.
