Abstract
R-CHOP chemotherapy is the standard therapy for B cell lymphoma and exerts an excellent efficacy. However, we sometimes encounter case reports on cicatricial stenosis, a complication of R-CHOP, which required surgery. In this paper we present eight cases of gastrointestinal malignant lymphoma in which cicatricial stenosis developed after the chemotherapy required surgical resection in our hospital. The histological type was diffuse large B-cell lymphoma in all cases and R-CHOP chemotherapy was conducted in them. The stenosis most frequently appeared in 1-4 courses of R-CHOP. These stenoses were considered to be located in areas where the lymphoma lesions existed, including the duodenum in one, the stomach in three, the ileocecal region in two, the ileum in one and the ascending colon in one case. Surgical resection was performed in seven cases that resulted in pathological CR. In the remaining one case in which bypass operation was done, the outcome was rated as clinical CR. Histopathologically the tumors disappeared and were replaced with fiber tissue. Six patients are alive without recurrence, one patient died of other disease and one died of this disease. We must remain alert for passage disturbance due to cicatricial stenosis which can occur as a complication after the chemotherapy.
