Abstract
In recent years, breast-conserving therapy comprising partial mastectomy followed by irradiation has been established as the standard local therapy for breast cancer. We present our experience with a case of leiomyosarcoma developed 19 years after postoperative irradiation for right breast cancer, together with a review of the literature.
The case involved a 65-year-old woman complaining of a right subclavian tumor. There were previous histories of undergoing right breast-conserving operation, ipsilateral axillary lymph node dissection, irradiation for the remnant mammary gland in 1995 at another hospital. Thereafter she had been disease-free up to the end of a five-year follow-up period. One month earlier, she noticed a right subclavian tumor and presented to our hospital. An elastic soft tumor with the size of a tip of the small finger was felt right above the right second rib. Furthermore another two tumors with the size of a rice grain were palpated in the outside of the tumor. In order to perform treatment and biopsy, these tumors were resected under general anesthesia. Immunohistology revealed ASMA+, desmin+, and BCL2+. Leiomyosarcoma after irradiation was thus diagnosed.
