Abstract
Squamous cell carcinoma (SCC) of the stomach is a very uncommon disease entity, accounting for approximately 0.1% of all gastric carcinomas. We report a case of 62-year-old man with SCC of the stomach who presented with sub-acute pyrexia and anorexia. A large, protruded tumor with regional lymphadenopathy was detected in the middle to lower third of the stomach. A preoperative endoscopic tumor biopsy suggested a histological diagnosis of poorly differentiated adenocarcinoma. A semi-urgent total gastrectomy was performed with curative intent. Histological examination of the resected specimen revealed SCC without any coexisting adenocarcinoma components. The patient received postoperative adjuvant chemotherapy with S-1 but died of aggressive tumor recurrence in the lymph nodes 9 months after the surgery. The clinical features, pathogenesis, and treatment of SCC of the stomach are discussed based on a literature review.
