Abstract
A 53-year-old woman was diagnosed with recurrent gastric gastrointestinal stromal tumor (GIST) with peritoneal dissemination and was admitted to our hospital for abdominal pain on day 136 of imatinib therapy. We performed urgent surgery under a diagnosis of hemoperitoneum from GIST. We resected a ruptured peritoneal dissemination that was causing bleeding. After surgery, she was followed-up without imatinib therapy. Two years later, peritoneal dissemination revealed exacerbation. We therefore performed reintroduction of imatinib therapy. However, she was admitted to our hospital in hemorrhagic shock on day 26 of imatinib therapy. We performed urgent surgery again due to ruptured peritoneal dissemination of GIST. Intraoperative findings revealed the ruptured GIST involved the transverse mesocolon. We performed transverse colectomy including the ruptured GIST.
Imatinib is a standard medication for recurrent GIST. Hemoperitoneum due to tumor rupture is an infrequent adverse event following imatinib therapy. We present a case and review the literature.
