Two Case Reports of Sixteen and Eighteen Multiple Neuro-endocrine Tumors

Abstract

A 67-year-old man and a 62-year-old man were diagnosed with multiple rectal neuro-endocrine tumors from endoscopic examination. In Case 1, laparoscopic intersphincteric resection and colo-anal anastomosis were performed. In Case 2, laparoscopic super-low anterior resection was performed. Histopathologically, the tumor in Case 1 was confined to the submucosal layer, and showed lymphatic invasion. Case 2 showed venous vessel invasion and lymph node metastasis. Multiple rectal neuro-endocrine tumors are rare, and standard treatments have thus not been defined. Furthermore, according to some reports of neuro-endocrine tumors, the probability of lymph node metastasis is very high. We therefore consider that surgical resection with lymph node dissection should be performed.