A Case of KIT-negative, DOG1-positive Sigmoid Colon Gastrointestinal Stromal Tumor with Peritoneal Metastasis

Abstract

Cases of colon gastrointestinal stromal tumor (GIST) are rare, and the prognosis for such patients is poor compared with that for patients with gastric GIST. In general, a majority of GISTs show positive results on immunohistochemical staining for KIT. In the case of KIT-negative GIST, the identification of “Discovered on GIST-1 (DOG1)” staining is very useful. Here, we report a case of KIT-negative, DOG1-positive sigmoid colon GIST with peritoneal metastasis. Upon admission, the patient complained only of mild abdominal pain on the left side, and the disease progressed rapidly following sigmoidectomy.