Abstract
We report a case of pulmonary plasmacytoma with amyloid deposition. An 80-year-old man was referred to our hospital because of an enlarging pulmonary nodule in the right lower lobe. Chest CT scan showed a 14-mm solid nodule with air bronchogram in the right S9. We suspected lung cancer and performed surgery. Since the intraoperative pathological study by video-assisted thoracoscopic surgery showed no malignancy, we performed partial resection of the right lower lobe. Pathological studies revealed a growth of mature plasma cells at the lesion and interstitial amyloid deposition. Immunohistochemistry showed a large number of IgA-κ positive plasma cells. The final pathological diagnosis was extraosseous plasmacytoma with nodular pulmonary amyloidosis. M-protein was not detected in the serum and urine by immunoelectrophoresis and a bone marrow examination revealed no abnormalities. The patient has been free from recurrence for two years after the operation.
Extramedullary plasmacytomas arise mostly in the upper airway or oral cavity but very rare in the lung.
