Abstract
Two very rare cases of gastric adenocarcinoma with enteroblastic differentiation (GAED) are reported.
Patient 1 was a 82-year-old man with a 55-mm, type 2 lesion in the anterior wall of the gastric antrum. Gastric cancer was diagnosed, and a laparoscopic distal gastrectomy was performed. Histopathology showed well-to-moderately differentiated adenocarcinoma and partial poorly differentiated adenocarcinoma with clear cytoplasm. Immunostaining was negative for alpha-fetoprotein (AFP) and glypican 3, and positive for Sal-like protein 4 (SALL4). The patient was diagnosed with GAED [The literal translation is “adenocarcinoma with enteroblastic differentiation”. Please confirm here and below.]. Six months postoperatively, during treatment with adjuvant chemotherapy, liver metastases and periaortic lymph node metastases were noted.
Patient 2 was a 90-year-old man with a 19-mm, type 1 lesion in the posterior wall of the lesser curvature of the gastric cardia. Gastric cancer was diagnosed, and a laparoscopic proximal gastrectomy was performed. Histopathology showed moderately differentiated adenocarcinoma and partial papillary adenocarcinoma with clear cytoplasm. Immunostaining was negative for AFP and positive for glypican 3 and SALL4. The patient was diagnosed with GAED, and 9 months postoperatively, liver metastases were noted.
GAED is a very rare disease with a poor prognosis. These cases are reported along with a discussion of the relevant literature.
