Abstract
A 62-year-old man complaining of epigastric discomfort was found to have a type 3 tumor at the posterior wall of the upper body of the stomach by esophagogastroduodenoscopy. Following a biopsy, moderately differentiated tubular adenocarcinoma (tub2) was diagnosed. Laparoscopic-assisted total gastrectomy was performed. Histopathology revealed that the tumor was mainly composed of invasive micropapillary carcinoma (IMPC) where adenocarcinoma cells showed a micropapillary growth pattern with lacuna formation between the surrounding stroma, accompanying by the coexistence of tub2. The final diagnosis of the tumor was 35 × 30 mm in diameter, T3 (SS), ly2, v2, N2 (3/60), and Stage IIIA. Adjuvant chemotherapy with TS-1 was conducted. No recurrence has occurred as of 5 years after the operation.
IMPC effects the breast, lung, salivary gland, urinary bladder, and large intestine. It is a highly malignant tumor associating with lymphatic invasion and lymph node metastasis in high frequencies, and hence carries a poor prognosis. As clinical reports on IMPC of the stomach are extremely few, we present our case with a review of the literature.
