Abstract
Anaplastic carcinoma of the pancreas is a subtype of invasive ductal carcinoma that has a poorer prognosis than common pancreatic ductal carcinoma. We report two cases of anaplastic carcinoma originating from intraductal papillary mucinous neoplasm with long-term survival. The first case was 66-year-old woman who presented with obstructive jaundice and a multilocular cystic tumor 35 mm in diameter with contrast enhancement was found in the pancreatic head. The patient was diagnosed with branch main duct intraductal papillary mucinous carcinoma and she underwent subtotal stomach-preserving pancreaticoduodenectomy. The pathological diagnosis was anaplastic carcinoma originating from intraductal papillary mucinous neoplasm, osteoclast-like giant cell type. The patient remains disease-free 6.5 years postoperatively. The second case was a 70-year-old woman who presented with abdominal distention and she was found to have main pancreatic duct dilation. The patient was diagnosed with main duct intraductal papillary mucinous carcinoma and she underwent subtotal stomach-preserving pancreaticoduodenectomy. The pathological diagnosis was anaplastic carcinoma originating from intraductal papillary mucinous neoplasm, spindle-cell type. The patient remains disease-free 5.5 years postoperatively. In anaplastic carcinoma, there is a different clinical course depending on histological type and origin, and cases with long-term survival after R0 resection have been reported, similar to our experiences.
