Abstract
We report an extremely rare and suggestive case of metachronous bilateral breast cancer associated with neurofibromatosis type1 (NF1) and complete visceral inversion (situs inversus totalis). Metachronous left breast cancer occurred 10 years after right breast cancer which was non-palpable carcinoma detected by screening examinations. She had an identical twin who also developed breast cancer. It was suggestive that twin sisters from a family with NF1 had breast cancer NF1 also called von Recklinghausen disease is an autosomal dominant hereditary disease characterized by multiple café au lait spots, axillary and inguinal freckling and multiple cutaneous neurofibromas. It is caused by mutations in the NF1 gene which is located on chromosome 17q. Recently NF1 is recognized as one of the hereditary cancer predisposition syndromes. Therefore, recognition of this syndrome has significant importance of cancer screening.
