Abstract
The patients were a 63-year-old and 61-year-old male siblings with familial adenomatous polyposis (FAP). During follow-up after subtotal colectomy, both were diagnosed as having early gastric cancer with multiple adenomas in the pyloric antrum ; distal gastrectomy, and not endoscopic excision, was performed owing to the presence of the cancer lesion. The disease was classified as pT1a (M)N0M0, pStage IA. There are only 19 reported cases of gastric cancer associated with FAP in Japan. Ten out of 15 mucosal or submucosal invasive lesions were operatively resected in the foregoing reports. Although malignant transformation of multiple adenomas is known, H. pylori infection was considered as the predisposing factor for the malignancy in our cases. It is important to screen FAP patients for H. pylori infection and carefully decide the surgical procedure for early gastric cancer in patients with FAP.
