Abstract
A 52-year-old man, diagnosed with obstructive sigmoid colon cancer with liver and lung metastases, underwent a sigmoidectomy. After the operation, he received FOLFOX + panitumumab therapy. A follow-up computed tomography scan after 8 cycles of treatment revealed intraperitoneal free air, retroperitoneal free air, vertical emphysema, and diffuse intramural air in the ascending and transverse colon. However, the abdominal examination was unremarkable, and there was no evidence of intestinal necrosis or peritonitis. Therefore, we diagnosed the patient with pneumatosis cystoides interstinalis (PCI). We treated him without surgery, and gradually the peumatosis coli and emphysema decreased. After the treatment of PCI, he received chemotherapy without panitumumab, and PCI did not recur. Recently, PCI caused by cetuximab has been reported. However, cases of PCI caused by panitumumab are rare. We report this case of PCI occurring during panitumumab therapy, along with a review of the literature.
