A Case of Neurofibromatosis Type I Associated with Gastric Cancer

Abstract

Neurofibromatosis type 1 (NF1 ; von Recklinghausen's disease) is a condition characterized by multiple café-au-lait spots and neurofibromas. We present a case of NF1 associated with gastric cancer. The patient was a 71-year-old woman who began to develop skin coloring spots in childhood and neurofibromas in the skin in her twenties. She was pointed out anemia and was diagnosed as having a type 1 tumor on the posterior wall of antrum of the stomach by upper gastrointestinal endoscopy. She underwent endoscopic submucosal dissection for gastric cancer which was diagnosed as moderately differentiated adenocarcinoma. The pathological examination revealed invasion of small vessels and vertical stump, then she underwent distal gastrectomy.

It has been reported that NF1 is frequently associated with non-epithelial tumors including neurogenic tumors, but there are few reports that NF1 is associated with epithelial tumors.