Solitary Adrenal Metastasis of Breast Cancer Treated Laparoscopically—A Case Report—

Abstract

A 76-year-old woman diagnosed with carcinoma of the right breast underwent total mastectomy at the age of 68 years. Histopathological examination of the resected specimen revealed scirrhous carcinoma and the pathological stage was T2N1M0 Stage IIB, estrogen receptor (ER) (+), progesterone receptor (PgR) (+), human epidermal growth factor receptor 2 (HER2) (0). Therefore, she received adjuvant hormonal therapy for 5 years. During the 8^th postoperative year, a right adrenal gland tumor was identified by computed tomography with increasing levels of serum tumor markers. She underwent diagnostic and therapeutic laparoscopic right adrenalectomy. Histopathological examination of the specimen revealed an ER (-), PgR (-), HER2 (3+) tumor, which histopathologically differed from the primary tumor. Immunohistochemical examination revealed positive expression of gross cystic disease fluid protein-15 and mammaglobin, and the adrenal tumor was diagnosed as breast cancer metastases. The patient has shown no recurrence 2 years after the adrenalectomy.

Breast cancer often metastasizes to the adrenal glands as a component of systemic metastasis during the terminal stages of disease, and isolated metastases are rare.

We recommend surgical removal in these cases for different breast cancer of the treatment according to biology.