Good's Syndrome Developed after Extended Thymectomy for Thymoma—A Case Report—

Abstract

The case involved a 67-year-old woman who had undergone extended thymectomy for an anterior mediastinal tumor in March 2017. Pathological findings revealed World Health Organization (WHO) classification type AB thymoma. A year after thymectomy, she developed pneumonia and was treated. From then, she had recurrent bouts of pulmonary infection and this could be explained by a fact that the absence of immunoglobulin was clarified by further examination. Thus, she was diagnosed with Good's syndrome when one and half years had elapsed after thymectomy. She began receiving intravenous immunoglobulin and long-term macrolide maintenance therapy. She followed an uneventful course after the treatment for 6 months. Good's syndrome is a comparatively rare entity associated with hypogammaglobulinemia and thymoma. However, the exact cause of this rare syndrome remains unknown and recurrent pulmonary infection carries poor prognosis. It also remains controversial that what therapy is effective including surgical resection of thymoma. Further accumulation of clinical cases would be mandatory.