Locoregional Surgery for Local Control in Patients with De Novo Stage IV Breast Cancer

Abstract

Introduction : The role of local treatment in patients diagnosed with de novo stage IV breast cancer is unclear. The impacts of locoregional surgery (LRS) on survival and local control were examined retrospectively.

Methods : The subjects were 55 patients diagnosed with de novo stage IV breast cancer at our hospital between January 2006 and December 2020. The patients were divided into two groups : group A, 10 patients who underwent surgery during treatments ; and group B, 45 patients who did not. The treatment results and prognosis were compared between the two groups retrospectively.

Results : The median survival time was 1090 days in group A and 555 days in group B, with no significant difference (p=0.14). In Group A, 8 patients died, with a median survival of 304 days and a one-year survival rate of 43.8%. Postoperative local recurrence was observed in two cases, but no cases required local treatment at the end of life.

Conclusion : LRS for de novo stage IV breast cancer may contribute to better local control. It can be an option after detailed examination of local and metastatic disease and other treatment possibilities such as Mohs ointment.