A Case of Crohn's Disease Associated with Simultaneous Multiple Small and Large Bowel Cancers

Abstract

Crohn's disease is a chronic inflammatory bowel disease, and long disease duration leads to a high risk of cancer-associated inflammation. It is known that ulcerative colitis is associated with multiple cancers or high-grade dysplasia. However, few reports of multiple cancers in Crohn's disease have been published in Japan. A rare Japanese case of Crohn's disease associated with synchronous multiple cancers, which was found by total proctocolectomy, is presented. The clinical presentation, treatment, and epidemiology of multiple cancers in Crohn's disease are discussed in this case report with consideration of the differentiation of those in Japan and in other countries.