Risk Factors of Causing Acute Kidney Injury after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Using Cisplatin

Abstract

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy is effective for selected patients with peritoneal carcinomatosis. Acute kidney injury after usage of cisplatin has been a matter. This study was made to spotlight the matter.

Data of a total of 63 cases treated by intraperitoneal chemotherapy using cisplatin were analyzed to investigate the association of acute kidney injury with 17 factors representing patients' profiles and intra- and post-operative parameters. Sodium thiosulfate was not used for renal protection.

As a result, acute kidney injury of grade 2-4 or grade 3-4 was detected in six or three cases, respectively. Risk factors associated with events of grade 2-4 were operation time, the amount of colloid administered, and intraoperative urine volume, but no independent risk factor was detected. A risk factor associated with grade 3-4 events was the amount of colloid administered. It was concluded that acute kidney injury was detected in about 10% of the cases and could be reduced by refrain from colloid administration and maintaining intraoperative urine volume. However, additional renal protection should be considered for further safety.