A Case of Intramural Cystic Lesion of the Gallbladder with Low-grade Atypical Mucinous Epithelium

Abstract

A 71-year-old man who had been pointed out having gallstone was diagnosed with cholelithiasis and adenomyomatosis by preoperative abdominal MRI. Laparoscopic cholecystectomy was performed. The resected specimen included a 25-mm submucosal tumor-like ridging that was found to be a multilocular cystic lesion on the section. Histopathology disclosed adenmyomatosis and multilocular cystic lesion due to mucinous epithelium localized in the gallbladder wall. The cystic epithelium was partly positive for MUC5AC and MCU6, that characterized of gastric-type mucus, with a part comprising low-grade atypical epithelium. Our case was of an intramurally growing cystic lesion localized in the gallbladder wall. Morphologically, it is designated as intramural multicystic mucinous neoplasm with low-grade intraepithelial neoplasia. Due to the rarity of pathological features, we here present this case.