A Case of Multiple Sporadic Gastrointestinal Stromal Tumors in the Stomach and Jejunum with Different KIT Gene Mutations

Abstract

Sporadic multiple gastrointestinal stromal tumors (GISTs) are very rare, and their cause and pathogenesis are still unknown. A case of multiple sporadic GISTs in the stomach and jejunum is reported. The patient was a 75-year-old man. Contrast-enhanced computed tomography showed incidentally a 4-cm-diameter mass in the body of the stomach and a 2-cm-diameter mass in the jejunum, with different contrast effects. Surgery was performed to differentiate GIST, other submucosal tumors, or metastatic GIST. Histopathological examination showed that both tumors were positive for CD117 and CD34, and they were diagnosed as GISTs. Since the patient had no medical or family history of a cause for multiple GISTs, and CD34 staining was clearly different between the two tumors, genetic testing was performed, which showed different KIT gene mutations. The patient was thus diagnosed as having multiple sporadic GISTs in the stomach and jejunum. There is no consensus regarding the prognosis or treatment strategy for multiple GISTs. Evaluation of further clinical cases is needed.