A Case of Metachronous Bilateral Breast Cancer in a Patient with Bloom Syndrome

Abstract

The patient was a 25-year-old woman who had been attending our pediatric department due to Bloom syndrome. In May 20XX, she presented to our department with a self-detected mass in her left breast, which was diagnosed as left breast cancer (HER2 type). Given the increased risk of secondary cancers from radiation and chemotherapy in patients with Bloom syndrome, she underwent a left mastectomy with axillary lymph node dissection, followed by postoperative chemotherapy with trastuzumab alone. During a follow-up at our department, three years after the surgery, right breast cancer was suspected based on breast ultrasound and mammography findings. Further examination confirmed the diagnosis of right breast cancer (TN type), and she underwent a right mastectomy with axillary lymph node dissection. Adjuvant chemotherapy was not administered as well, and a strategy of observation was adopted. X years have passed after surgery, and she remains in disease-free survival. Due to the extreme rarity of Bloom syndrome, we present our case of the disease with metachronous bilateral breast cancer.