Abstract
Seishu Hanaoka (1760-1835) was a village physician of Kishu, currently Wakayama prefecture, and has been widely known as the first to perform the excision of breast cancer on a woman under general anesthesia by administrating his oral anesthetics “Mafutsu-san” in October of 1804.
As he did not write any medical books and detailed records on his family himself, many things associated with him, his family and the developing process of “Mafutsu-san” remain unknown to us. For example, the name and age of his youngest daughter has never been clarified.
The author repeated animal experiments using “Mafutsu-san” the same as Seishu did, to understand the process of “Mafutsu-san” development.
Furthermore, the author found the necrology of Jizo-ji temple, formerly Hanaoka's family temple, to add new information about his family tree. The thoughts of Seishu Hanaoka on medicine, such as internal medicine and surgery should not be specialized but should be united, and patients should be treated as living bodies and as a whole, considering their pathophysiology, can be accepted as true even in our day.
