Abstract
Pharmacokinetic-pharmacodynamic models of propofol have been widely used to estimate the response of the Bispectral Index (BIS) . The pharmacokinetic parameters, utilized in these models, were obtained from intermittent blood samples obtained from a limited number of subjects, and are not guaranteed to be ideal for the estimation of the BIS. Moreover, these models have not taken adequate consideration of a delay in the BIS response. In this paper, parameters of a pharmacokinetic-pharmacodynamic model and the delay were identified from measurements of infusion rate and the BIS during surgery. The identified parameters decrease the estimation error of the BIS response compared with the standard parameters. The importance of adequate consideration of the delay is also suggested.
