Abstract
We investigated the effects of a novel, highly cardioselective short-acting β-blocker, landiolol on cardiac index with or without propofol anesthesia. Seven ASA class I - II patients received landiolol (0.1 mg/kg) before induction of anesthesia and during a target controlled infusion of propofol (effect-site concentration 2-4μg/ml) . We measured beat-to-beat heart rate (HR) , cardiac index (CI) , stroke volume index (SVI) , and end diastolic volume index (EDVI) by using the method of transthoracic bioimpedance measurement. HR and CI significantly decreased after landiolol injection in awake patients (86% and 89% of control value, respectively) , while SVI and EDVI did not change. This action was independent of propofol anesthesia. Our results suggest that 0.1 mg/kg bolus injection of landiolol induces a decrease in CI, which is associated with a decrease in HR.
