Abstract
Preoperative amino acid infusion was reported to prevent postoperative hypothermia during both general anesthesia and spinal anesthesia, due to nutrient-induced thermogenesis. Amino acid solution was revealed to activate thermogenesis by stimulating muscle protein synthesis via elevated insulin secretion. Valine showed a greater thermic effect of inhibiting perioperative hypothermia than any other single amino acid or amino acid solution. Valine increased thermogenesis by specifically stimulating lipid metabolism in the brown adipose tissue. The thermic effect of Valine was ineffective in the human adult with no brown adipose tissue.
