Extravascular Lung Water and Pulmonary Vascular Permeability Index Measured by Transpulmonary Thermodilution Technique

Abstract

  The introduction of the transpulmonary thermodilution technique has made it possible to measure extravascular lung water (EVLW) and pulmonary vascular permeability index (PVPI). Evidence appears to support the usefulness of goal-directed fluid management by parameters derived from the thermodilution technique. EVLW represents the degree and severity of pulmonary edema. The EVLW measured by this method had been validated by the gravimetric measurement of lung weight in humans and statistically normal EVLW values have been reported. The PVPI can be utilized to differentiate between cardiogenic and non-cardiogenic pulmonary edema. The values of EVLW and PVPI impact significantly on fluid management, especially for the intensivist and anesthesiologist.