Abstract
It is recognized that neuropathic pain is very difficult to treat in pain-clinic practice. The reason that it is difficult to treat is considered a complexity of the mechanisms. Therefore, treatment of this condition must be done with adequate treatment strategies and/or pharmacological application.
In this article, the author describes nerve fibers, ectopic ion-channel, the contribution of nerve growth factor and lysophosphatidic acid to the development of ephapse and allodynia, the contribution of Glia to development of neuropathic pain, etc., concerning the mechanisms of neuropathic pain. Pharmacological management is also described.
