Abstract
Postoperative pain management is important for preventing perioperative complications. We created a novel slow releasing lidocaine sheet (SRLS) with polylactic-co-glycolic acid. The SRLS (30%, w/w) continuously released lidocaine for 1 week in vitro. A single treatment with the SRLS inhibited hyperalgesia and c-fos expression in the spinal cord dorsal horn for 1 week in postoperative pain model rats. And we created injectable slow releasing lidocaine particles (SRLPs) to grind the SRLS. The epidural injection of SRLPs produced prolonged anti-hypersensitivity in a rat model of postoperative pain with no major complications. We planned a phase 1 clinical trial. This study evaluated the efficacy and safety of the SRLS for normal mucous membrane of healthy male volunteers. In the future, we are going to try topical, epidural, and perineural administration of this slow releasing local anesthetic. These techniques can provide safer, easier, more effective postoperative pain management.
