Abstract
Specific preventative methods and a rapid response system are requirements for pain clinics. Studies have revealed that severe complications are associated not only with drugs such as pregabalin, antidepressants, and strong opioids, but also with peripheral nerve blocks. Early detection and an appropriate response are essential for addressing these complications. Issues to consider include stellate ganglion block, accidental intrathecal injection of analgesics, local anesthetic toxicity, serotonin syndrome, and opioid withdrawal syndrome. Advanced life support training in pain clinics is important for improving medical safety.