The Inhibitory Effect of Fluorescein on the Measurements of Hemoglobin Concentration by CO-oximetry

Abstract

Fluorescein, a fluorescent dye, has recently begun to be used in craniotomy to improve the tumor resection rate and avoid neurological complications.

Errors of CO-oximetry occurred in 3 patients after fluorescein administration.

Three patients were administered fluorescein at 1,000 mg intravenously. After administration, measurement of CO-oximetry using RapidPoint 405^TM（SIEMENS）including the hemoglobin concentration became impossible.

The errors are believed to have occurred as the measurement wavelength of CO-oximetry was near the wavelength of the absorption peak of fluorescein.