2020 Volume 40 Issue 3 Pages 221-226
Pulmonary artery pressure and pulmonary vascular resistance have been reported to be elevated during anaphylaxis in animal model studies, but little is known about changes in pulmonary artery pressure during anaphylaxis in human. We report a case of lymphangioleiomyomatosis with bronchospasm and pulmonary hypertension correlated with drug-induced anaphylaxis during general anesthesia.
A 49-year-old woman who was diagnosed with pulmonary lymphangioleiomyomatosis was scheduled for bilateral lung transplantation. After anesthetic induction and pulmonary catheter insertion, cefotiam was infused slowly. Following infusion, peak inspiratory pressure rose, and tidal volume immediately dropped sharply. At the same time, pulmonary artery pressure rose. We assumed that bronchospasm had occurred due to drug-induced anaphylaxis. Epinephrine administration immediately improved bronchospasm and pulmonary hypertension.
