2021 Volume 41 Issue 1 Pages 1-9
The effects of remifentanil（RF）and fentanyl（F）on heart rate（HR）and blood pressure（BP）under about the same effect site concentration were compared. Eighty patients with scheduled general anesthesia were randomly assigned to two groups, RF group and F group. The patients underwent general anesthesia. RF or F was administered so that the effect site concentrations were both approximately 3 ng/mL. Maximum percentage decrease from the baseline values of HR, systolic BP（SBP）, diastolic BP（DBP）, and mean BP（MBP）were compared between the two groups. The numbers of phenylephrine and atropine administrations were also compared. Regarding RF, the maximum reduction rate（％）of HR, SBP, DBP, and MBP was 20.3±15.9, 39.5±12.8, 35.0±12.2, and 35.7±12.1％（M±SD）, respectively. Regarding F, the maximum reduction rate（％）of HR, SBP, DBP, and MBP was 19.2±15.8, 34.9±11.8, 28.4±11.7, and 29.7±11.1％, respectively. As a result of detailed examination of the effects of lean body mass, age, phenylephrine, and atropine, it was considered that F and RF had almost the same effects on the maximum reduction rate（％）of HR, SBP, DBP, and MBP at approximately 3 ng/mL of the effect site concentration.
