2023 Volume 43 Issue 5 Pages 454-461
Ondansetron and granisetron（5-HT3 receptor antagonists）have recently become available in Japan for prevention of postoperative nausea and vomiting（PONV）, which has expanded the range of therapeutic options for PONV prophylaxis. However, these agents have been used as first-line agents for PONV prophylaxis in other countries for over 20 years. Recent guidelines for the prevention and treatment of PONV recommend the administration of additional antiemetic agents with newer mechanisms of action. In this article, we discuss the role of aprepitant and amisulpride（antiemetic agents）, as well as olanzapine, which have shown good efficacy for PONV prophylaxis in recent clinical trials.
