Abstract
The effect of pretreatment with either 30mg/kg or 60mg/kg of magnesium sulfate on the degree of fasciculation and of potassium release produced by lmg/kg succinyl-choline in 24 adult patients was compared with 12 saline pretreated patients as controls. The hemodynamic changes were also observed following larygoscopy and tracheal intubation. In both magnesium sulfate groups, Succinylcholine induced fasciculation was significantly prevented (p<0.01). In the control group, serum potassium increased by an average of 0.16±0.29 (S.D.) mmol/l. No patient in either magnesium group had an increase in serum potassium (30mg/kg: -0.14±0.29mmol/l, 60mg/kg: -0.37±0.64 mmol/l). The differences between control and both magnesium groups were statisti-tally significant (p<0.05).
There were no significant changes in heart rate by intubation in both magnesium groups. However, mean arterial pressure after intubation increased 48±18% in thecontrol group, 21±50% in the magnesium 30mg/kg group and 18±40% in the magne-slum 60mg/kg group as compared with before intubation. There was a significant difference between the control group and the magnesium 60mg/kg group(p<0.05).
