Abstract
We studied the effects of iontophoresis using several Ca channel blockers on pain relief in 18 healthy adult volunteers.
We administered 4% lidocaine with/without several Ca channel blocers (2mg of nicardipine, verapamil, or diltiazem). We used a NAKAHAMA pain meter to evaluate pain relief.
In the 4% lidocaine group and the Ca channel blockers without 4% lidocaine groups, the pain threshold doubled significantly in comparison with that of a control group. No significant differences in pain threshold were observed between the Ca channel blocker groups.
Compared with the lidocaine group, the nicardipine+lidocaine and diltiazem+lidocaine groups showed a tend toward a longer pain relierf effect. However, neither combination affected blood pressure or heart rate. Our results suggest that an analgesic effect can be achieved from the infiltration of Ca channel blockers through the skin.
