Abstract
The effects of preoperative administration of recombinant human erythropoietin (EPO) were studied on perioperative erythropoiesis in patients with hemodilutional autotransfusion (HAT).
At first, 21 hysterectomy scheduled patients (Hb_??_10g/dl) were divided into the EPO group (N=9) and the control group (N=12). The EPO group patients received EPO (3, 000 units) intravenously every other day for 12 days preoperatively and all patients received iron sulfate. In both groups, preoperative hemoglobin (Hb) levels were observed.
Secondly, 19 hysterectomy patients (Hb_??_11g/dl) with HAT were divided into the EPO group (N=5) and the control group (N=14). In these groups, postoperative Hb levels were observed.
There were no adverse reactions to EPO. The preoperative administration of EPO resulted in significant increase in preoperative Hb levels, and also tended to increase Hb levels postoperatively. We concluded that the administration of preoperative EPO promoted the erythropoiesis effectively on the perioperative anemia with HAT.
