Abstract
A clinical study was performed to evaluate midazolam with combined use of barbiturate for the induction of anesthesia, as well as to determine the optimal dosage of midazolam. Ninety-three patients for general anesthesia were randomly divided into three groups, and 2mg, 5mg or 8mg of midazolam, respectively, was administered intravenously. One minute after the administration of midazolam, 50mg of barbiturate was intravenously administered as an initial dose and an appropriate dose was added if necessarily. The similtaneous administration of barbiturate and midazolam is useful for the induction of anesthesia in spite of non fixed dose of body weight base of patients. We concluded that 5mg of midazolam was considered appropriate.
