Abstract
A 66-year-old male with bronchial asthma was scheduled for retropubic prostatectomy under general anesthesia. The patient developed anaphylactoid shock at reversal of neuromuscular blockade. The clinical manifestations were cardiac arrest following circulatory collapse, generalized erythema, facial edema and subcutaneous vasodilatation. Systemic vascular resistance was then low and bradykinin concentration was elevated. CPR with administration of noradrenaline was effective to overcome the shock state. In conclusion, bradykinin may be an important mediator of the pathophysiology of anaphylactoid shock in this case. Further, care has to be taken in using anesthetic drugs for patients with allergic history.
