Abstract
We studied the effects of 1 MAC of sevoflurane and isoflurane with 67% nitrous oxide on plasma-free catecholamine concentrations during gastrectomy.
Twenty patients were randomly divided into 2 groups: a sevoflurane group (n=10) and an isoflurane group (n=10). Anesthsia was maintained with oxygen, nitrous oxide, and end-expiratory concentration of 2.1% sevoflurane or 1.2% isoflurane.
In both groups, dopamine, noradrenaline and adrenaline concentrations significantly increased (p<0.05) 2 hours after the incision. The plasma-free adrenaline concentration in the isoflurane group was significantly higher than in the sevoflurane group (p<0.05). Blood pressure 2 hours after the incision in the isoflurane group was significantly increased (p<0.05).
In conclusion, the concentration of free adrenaline during surgical stress was more accelerated with isoflurane than with sevoflurane.
