Abstract
Laser ablation procedures under general anesthesia were performed in 20 patients. All patients complained of dyspnea at exercise or at rest. Mean preoperative FEV 1.0%, mean PaO2 and mean PaCO2 in room air were 31%, 71mmHg and 42mmHg, respectively. Induction of anesthesia was conducted with ketamine, midazolam and vecronium. Double lumen endtracheal tube was inserted. Anesthesia was maintained with isoflurane in 100% oxygen. We used pressure-controlled ventilation and limited peak airway presure to below 25cmH2O. Cardio-pulmonary data were recorded 20min after intubation (TLV-1), 20min after one lung ventilation (OLV) and 20min after re-expansion of the operative lung (TLV-2). PaO2 and tidal volume decreased from TLV-1 values to OLV values. Peak airway pressure and shunt increased from TLV-1 values to OLV values.