Abstract
To investigate the effect of laparoscopic cholecystectomy (LC) on the liver function, we measured serum alcohol dehydrogenase (ADH), glutathione S-transferase (GST-α) activ-ities, and portal venous blood flow by means of a transit time ultrasonic volume flowmeter before, during and after the operation. The patients were randomly divided into two groups; a GOS group (n=9) and a GOS+diltiazem group (n=9). In both groups, anesthesia was maintained with nitrous oxide-oxygen-sevof lurane. The GOS+diltiazem group received intravenous infusion of 5∼30μg•kg-1•min-1 of diltiazem, so that blood pressure during operation decreased to 80% of pre-operation. ADH and GST-α increased signifi-cantly during CO2 insufflation in both groups. Portal venous blood flow decreased to 30.3±9.4% and 37.9±9.5% of preoperative level in each group. There was no significant differ-ence in changes in ADH, GST-α activities and portal venous blood flow between the groups. These findings suggest that LC may cause mild liver damage due to hepatic ischemia during pneumoperitoneum.
